CAS No.: | 50-41-9 | Purity: | 99% |
Appearance: | White Powder | Feature: | Natural |
Product Name: | Clomiphene Citrate | Usage: | Pharmaceutical, Tablet |
Clomid is a mixed estrogen agonist/antagonist (activator/blocker) which, when bound to the estrogen receptor, puts it in a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor/Clomid complex, but others are blocked due to the change in shape. The result is that in some tissues Clomid acts as an antagonist — the cofactor used in that tissue cannot bind and so the receptor remains inactive — and in others Clomid acts as an agonist (activator), because the cofactors used in that tissue are able to bind.
Clomiphene Citrate
Alias: Clomid
CAS No: 50-41-9
Einecs No: 200-035-3
MF: C32H36ClNO8
MW: 598.09
Purity: 99%
Appearance: white power; Odourless..
Clomifene citrate is a drug treatment that stimulates your ovaries to release eggs.
Ovulation stimulation using clomifene citrate is a well-established, effective treatment. Clomifene citrate is the most widely used of all fertility drugs. Other drugs that may be used to treat ovulation disorders include metformin and bromocriptine
For athletic purposes, Clomid does not offer a tremendous benefit to women. In men however, the elevation in both follicle stimulating hormone and (primarily) luteinizing hormone will cause natural testosterone production to increase.
This effect is especially beneficial to the athlete at the conclusion of a steroid cycle when endogenous testosterone levels are depressed. If endogenous testosterone levels are not brought beck to normal, a dramatic loss in size and strength is likely to occur once the anabolics have been removed.
This is due to the fact that without testosterone (or other androgens), the catabolic hormone cortisol becomes the dominant force affecting muscle protein synthesis (quickly bringing about a catabolic metabolism). Often referred to as the post-steroid crash, it can quickly eat up much of your newly acquired muscle.
Clomid can play a crucial role in preventing this crash in athletic performance. As for women, the only real use for Clomid is the possible management of endogenous estrogen levels near contest time. This can increase fat loss and muscularity, particularly in female trouble areas such as this hips and thighs. Clomid however often produces troubling side effects in women (discussed below), and is likewise not in very high demand among this group of athletes.
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You usually take clomifene in pill form for five days early in your cycle, for up to six months at a time. A low dose of 50 mg is often used to start with.
(1) If you have regular cycles, you'll start taking the pills within five days of your period starting, preferably on about day two.
(2) If you're not menstruating at all or if your cycle is very irregular, your doctor will check that you're not pregnant. She'll then give you a synthetic version of the hormone progesterone, a progestogen called Provera.
(3) Progesterone works with oestrogen to keep your reproductive cycle regular. Provera will re-establish your periods. Once you're having periods, you can then start taking clomifene citrate.
(4) Ovulation generally occurs between five days and nine days after you've taken your last pill. Your fertility specialist may monitor your ovaries using ultrasound, at least during the first cycle. She'll look to see how your ovaries are responding and whether one egg follicle or more is preparing to release a mature egg into one of your fallopian tubes.
(5) You might ovulate and conceive in the first month of taking clomifene citrate. Or it can take a month or two of drug therapy for you to start ovulating regularly.
(6) Treatment may be continued for up to six cycles, as this is thought to be long enough to see whether your body is responding to the drug.
Test Items | Specification | Test Results |
Appearance | White or off-white powder | white powder |
Identification | UV conform | Conforms |
Organic nitrogenous | Conforms | Conforms |
Citrate | Conforms | Conforms |
Water | Not more than 1.0% | 0.38% |
Heavy water | Not more than 0.002% | Conforms |
Related impuries | Related compound A:Not more than 2.0% | 0.86% |
Individual:Not more than 0.5% | 0.38% | |
(Z)isomer | Conforms | Conforms |
Organicvolatile impuritise | Conforms | Conforms |
Assay | Between98.0~102.0% | 99.2% |
Conclusion | This batch is complies with USP 32. |
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